Evolve ®(preservative free) - reserved for patients unable to tolerate preservatives. Expiry of multi-dose bottle is 3 months after opening for the Evolve brand. Thông báo cho Bác sĩ những tác dụng không mong muốn gặp phải khi sử dụng thuốc. 4.7 Hướng dẫn cách xử trí ADR:

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Grey / Non-Formulary (undergoing assessment): Work is ongoing and will be reviewed at a future APC meeting. For use only in patients with moderate to severe dry eye with corneal epithelial stains and on the recommendation of a specialist. A third study analyzing Refresh and Systane products compared the effects of Refresh Liquigel ® and Systane ® on corneal staining and symptomatic improvement in 60 patients. 30 A reduced sum score of corneal staining and a reduction of corneal staining from baseline were only observed in the Refresh Liquigel ® group ( P=0.008 and P=0.019, respectively). Patient’s tear preference and comfort were also analyzed in this study; however, patients were not blinded to the artificial tear assigned. Using one eye for each artificial tear, patient preference was recorded 5 minutes after application with 36% of patients preferring Refresh and 24% preferring Systane. Limited value may be drawn from the subjective component of this study since unilateral symptoms may have been present in the study participants. If you forget to use your eye drops, use them when you need them next or when it’s time for your next dose. What if I use too much?At 90 minutes after application, Systane Ultra users maintained BCVA for 9.17±0.0365 seconds compared to 6.84±0.0365 seconds of maintained BCVA in Refresh Optive users On a unit scale of 0–15, with 0 being no staining and 15 the most staining, corneal staining after 42 days of treatment with Systane Ultra showed 2.9±1.8 units of corneal staining compared to 4.2±2.8 units of corneal staining in those treated with Refresh Optive

blink regularly (ask your doctor or eye specialist for advice on blinking exercises if you need them) gently massaging your eyelids with your finger or a cotton bud – this pushes the oils out of the glands Clinical trial revealed patient preference for Refresh Liquigel (36%) compared with Systane (24%). Mean corneal inferior staining was only significantly reduced in patients treated with Refresh Liquigel After 1 month of therapy, TBUT was significantly increased by 2.4 seconds with Blink Tears while Systane Ultra showed no statistically significant increase in tear film

7. Cautions with other medicines

Optive PLUS ™ also protects the tear film from evaporation by improving the lipid layer. Like Optive ™, Optive PLUS ™ contains the preservative PURITE®. The special thing about the preservative PURITE® is that light breaks down into the natural components of tears (sodium and chloride, oxygen and water). Corneal staining reduced greater from baseline with Refresh Liquigel than Refresh Tears, but more adverse events occurred with the Liquigel Carboxymethylcellulose-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 2 June 2022].Available from: A supporting prescribing guideline may be requested which must have been agreed by the relevant secondary care trust DTCs and approved by the Nottinghamshire APC. Supply issue with Clinitas 0.2% gel, Viscotears 2mg/g liquid gel, Artelac Nighttime 0.2% gel and GelTears 0.2% gel (Reviewed Nov 23)